| 中文名称 | 双香豆素 |
|---|---|
| 中文别名 | 3,3'-亚甲基二(4-羟基-2H-苯并吡喃-2-酮) |
| 英文名称 | Dicoumarol |
| 英文别名 | 3,3'-Methylenebis(4-hydroxy-2H-chromen-2-one) |
| CAS号 | 66-76-2 |
| 分子式 | C19H12O6 |
| 分子量 | 336.29 |
| 存储条件 | RT避光 |
| 保质期 | 1年 |
| 溶解性 | 溶于吡啶(50mg/ml) |
| 纯度： | ≥98% |
| 产品介绍： | 一种NAD(P)H:醌氧化还原酶1(NQO1)和PDK1的抑制剂。 Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant that functions as a functional vitamin K depleter (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments as an inhibitor of reductases. Like all 4-hydroxycoumarin drugs it is a competitive inhibitor of vitamin K epoxide reductase, an enzyme that recycles vitamin K, thus causing depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes. These compounds are not antagonists of Vitamin K directly—as they are in pharmaceutical uses—but rather promote depletion of vitamin K in bodily tissues allowing vitamin K's mechanism of action as a potent medication for dicoumarol toxicity. The mechanism of action of Vitamin K along with the toxicity of dicoumarol are measured with the prothrombin time (PT) blood test. |
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注意：
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备注:
以上数据均来自公开文献,博奥拓达暂未进行独立验证,仅供参考。
These protocols are for reference only. Biotopped does not independently validate these methods.
